Current Projects

Our lab explores many avenues surrounding Ischemia–reperfusion injury (IRI). IRI is a critical determinant of tissue damage and functional outcomes following trauma, reconstructive procedures, and transplantation, and is widely studied across both small and large animal models. In small animal models, particularly rodents, IRI is well characterized at the molecular and cellular levels, with a strong emphasis on oxidative stress, inflammatory signaling, and apoptotic pathways due to their experimental flexibility and reproducibility. Large animal models, including porcine and ovine systems, provide greater translational relevance by more closely mimicking human physiology, vascular architecture, and biomechanical loading conditions. These models enable the use of clinically applicable outcome measures such as gait analysis, motor and sensory function testing, and advanced imaging.

Peripheral nerve injuries remain a significant clinical challenge, particularly in cases involving large defects or mixed motor–sensory nerves. Autologous nerve grafting continues to serve as the standard of care; however, it is frequently associated with incomplete functional recovery and donor-site morbidity. Emerging strategies, including bioengineered nerve conduits, cell-based therapies, and neuromodulation, have demonstrated potential to enhance regenerative outcomes, particularly when applied in combination. Large animal models are increasingly utilized to support clinical translation, as they more accurately replicate human nerve anatomy and functional demands.

An osseointegrated neural interface represents an emerging technology in prosthetic limb integration, combining a direct skeletal attachment with implanted neural recording and stimulation capabilities to create a more stable and intuitive connection between the user and an external prosthesis. In our lab, this approach is being investigated in an ovine model as a means to improve motor control, sensory feedback, and long-term device reliability compared to traditional socket-based prosthetics. By anchoring directly to bone and interfacing with peripheral nerves or muscle signals, osseointegrated systems can reduce issues such as socket discomfort, soft tissue movement, and signal variability.

A large part of the lab is dedicated to improving education in both the laboratory and clinical setting. More specifically, the development of the blue blood chicken thigh model has proven to be successful in teaching a number of microsurgical techniques including and end-to-end anastomosis. The lab is also focused on creating low-cost synthetic vessels for microsurgical training, in an attempt to further provide more accessibility in the field.

Additionally, we have created a portable, 3D printed, microscope to aid in microsurgical teaching and improve access to cutting edge technology.